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Retatrutide's discontinuation rate in SURMOUNT-5 was 12.4%, compared to 7.1% for tirzepatide in SURMOUNT-1 and 4.5% for semaglutide in STEP 1

Jun 2 2022;doi:10.1001/jamaophthalmol.2022.1640 Chong ET, Kreis AJ, Wong TY, et al

Sulfate-Free Base Barrier Preservation SLS and SLES destroy the acid mantle, raising skin pH and compromising the moisture barrier making all subsequent serums less effective

Using a high-quality water filter can also help reduce the initial intake of heavy metals

DPP-4 inhibitors increase the endogenous GLP-1 concentrations ~2-3-fold, GLP-1 receptor agonists lead to 8-10-fold concentrations

Can I use a GLP-1 patch if I have very sensitive skin