When you drink coffee on an empty stomach while taking semaglutide or tirzepatide, the caffeine stimulates gastric acid production and can trigger nausea or stomach upset in some patients, especially during the first few weeks of treatment
Whether that gain holds up against retatrutide's already-stronger backbone is the open empirical question additive effects often diminish as the base compound's efficacy increases
[DOI] [PubMed] [Google Scholar] 13.Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, Mereu R, et al
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