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Patients who experience intolerable side effects at any dose can remain at their current level longer before titrating upward

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Special medical attention is important, among other things, in cases of: existing gastrointestinal conditions type 2 diabetes or other metabolic disorders cardiovascular disease or increased cardiovascular risk regular use of other medications previous intolerance to GLP-1 or GIP/GLP-1 medications unclear symptoms before starting treatment pregnancy, breastfeeding, or plans to become pregnant Patients can find more information about the tolerability of established GLP-1 medications, for example, on our page about side effects of Wegovy with semaglutide

However, most degradation is invisible at the molecular level