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Annu Rev Biochem 52:711760 Njalsson R, Norgren S, Larsson A, Huang CS, Anderson ME, Luo JL (2001) Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase

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5.4 Gaps in current knowledge and future directions While genomic plasticity contributes to resistance, the precise evolutionary trajectory of resistant Leishmania strains under drug pressure remains unclear, necessitating longitudinal studies to track genomic changes in response to treatment (Santi and Murta, 2022)

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They induce an immune response again st the spike protein on the viruss surface, blocking its entry into cells and providing an antiviral effect

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