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Traub S, Meier DT, Schulze F et al (2017) Pancreatic cell-derived glucagon-related peptides are required for cell adaptation and glucose homeostasis

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doi: 10.1097/CRD.0000000000000513, 111

However, HFD-feeding has been shown to induce alpha-cell hyperplasia prior to the expansion of beta-cell mass in mice (17, 100), and similarly, studies performed in normoglycemic non-human primates demonstrate that alpha-cell mass was more significantly augmented in response to the increased duration and severity of obesity than that of beta-cells (101)