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In relation to COX-2, polyphenols may have several effects: (i) Some studies have suggested that polyphenols may inhibit COX-2 activity [239], and (ii) wine polyphenols have been shown to exert an antineoplastic effect on the androgen-resistant PC-3 cell line through inhibition of NF--mediated transcriptional activity of the COX-2 promoter

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Methods Bioinformatics analysis The sequences of the enzymes of the transsulfuration pathway cystathionine beta synthase (CBS) and cystathionine gamma lyase (CGL) of Saccharomyces cerevisiae were collected from NCBI Database

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