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In addition to glucose control, emerging evidence suggests semaglutide may exert anti-inflammatory effects and improve vascular health by reducing inflammatory cytokines

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Even though low mGPDH is associated with type 2 diabetes, disruption of the gene encoding it in mice does not impair GSIS, suggesting the malate/aspartate shuttle may compensate for the lack of glycerol-3-phosphate shuttle [25, 26]