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The same group showed NNMT inhibition simultaneously elevated both NAD+ and SAM in adipose tissue, suggesting a dual metabolic benefit mechanism of significant research interest

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Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Landais A

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