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In addition, PLE inhibits the oxidation of glutathione and acts as a direct ROS absorber against superoxide anion, hydroxyl, oxygen and oxygen peroxide

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This review explores the biology of aging, the role of senescent cells in AD pathology, and various senotherapeutic approaches such as senolytics, dampening the SASP (senescence associated secretory phenotype), senescence pathway inhibition, vaccines, and prodrugs