Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase
2019;14(1):e0210389
In addition to dopamine, norepinephrine, and epinephrine, the VMAT transporters, in particular VMAT2, are responsible for vesicular import of serotonin (5-HT), histamine, and several trace amines such as the tyramines [para-tyramine ( p -tyramine), meta-tyramine ( m -tyramine), 3-methoxytyramine, and N-methyltyramine], -phenylethylamine (-PEA), and thyronamine (3-iodothyronamine)
A few patients report receiving oral tablets that produced no noticeable appetite suppression or weight loss
Understanding these costs is essential for patients considering this treatment option
These findings collectively validate that precise intervention in this axis may markedly augment chemotherapeutic efficacy, though the successful clinical translation of such combinations require careful patient stratification based on molecular and histological subtypes