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This process not only directly generates excessive ROS by initiating the non-enzymatic Fenton reaction but also enhances the activity of lipoxygenase (ALOX) or EGLN prolyl hydroxylases (also known as PHD) [1, 19, 20]

If your weight remains stable for 812 weeks despite maintained appetite suppression and consistent diet, your plateau may signal tolerance or metabolic adaptation requiring dose adjustment or medication change

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Weeks 3-4: Bloating often peaks during this period if you remain at the starting dose, or it resurges if you have just escalated

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2012 Feb;51(1):1-18