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Participants were randomly assigned to either one of three groups: placebo, 25 mg, or 50 mg of methylcobalamin, given twice a week, by injection into the muscle

Developed by the Karst group at the University of Mnster in Germany, DMNTH is synthesized via substitution reactions on melamine, where the melamine base molecule plays a specific role in the detectability, reactivity, and polarity of the reagent

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doi: 10.1126/science.1198719

Vitamin C was administered at a dose of 500 mg/day for 1 month during the initial stage of scurvy treatment