This difference in scope is the central reason the two are discussed as potentially complementary rather than redundant
to UV rays
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NEJM 2023 What this means: Even the lowest dose (1mg) produced clinically meaningful weight loss (-8.7%) The 12mg dose showed no plateau at 48 weeks
N Engl J Med 362:16751685 Cusi K, Orsak B, Bril F et al (2016) Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial
Seminars in Thrombosis and Hemostasis , 2000, 26: 255-61