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This can come in the form of prescription medications such as Ozempic, Mounjaro or Wegovy, supplements and fibres, or foods and dietary strategies and theyve become a go-to fix for weight management goals

At the general population level, AOMs will have a meaningful impact on mortality

[1] [3] Given that obesity is itself a major cardiovascular risk factor, significant weight loss is generally associated with improvements in blood pressure, lipid profiles, and markers of systemic inflammation, all of which may benefit heart health

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Whether this mechanism translates into greater weight loss than dual-agonist therapies remains a hypothesis no head-to-head clinical trials have yet been conducted

Consequently, we focused our analysis on eWAT and demonstrate that Retatrutide reverses this dysfunctional phenotype through coordinated changes in gene expression governing lipid turnover, mitochondrial biogenesis, and extracellular matrix remodeling