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However, in one year-long phase 3 trial involving 2,000 severely obese patients, disappointing results were seen in the axokine-treated group [75]

Authors contributions Analysis & interpretation of data (PJ, EB, ML), statistical analysis (PJ, EB, ML), manuscript writing (PJ, ML), critical revision (EB, ZY, MV, ML), material support (MV).

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3.3.1 Background Anxiety disorders represent a group of persistent neuropsychiatric conditions affecting approximately 4.05% of the global population, with prevalence rising by over 55% since 1990 (Javaid et al., 2023)