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Indirect methods are used to obtain lead compounds by analyzing the three-dimensional structure and conformation of the active small molecule to create a pharmacophore model and subsequently searching a small molecule library for compounds that match the pharmacophore model

Antidepressants amitriptyline, fluoxetine, and traditional Chinese medicine Xiaoyaosan caused alterations in gut DNA virome composition and function in rats exposed chronic unpredictable mild stress

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Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Sundaraneedi, M

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