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The results of clinical trials have not matched expectations based on the positive results from preclinical studies

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167 These pathways, which are normally active in embryonic development and tissue homeostasis, are frequently dysregulated in CSCs, thereby promoting tumor progression and therapy resistance

DSP declares associations to Abbott, Alkaloid, AstraZeneca, Boehringer Ingelheim, Berlin-Chemie, Eli Lilly, Galenika, Krka, Merck, Novo Nordisk, PharmaSwiss, Sanofi-Aventis, Servier, Viatris, and Worwag Pharma

The threshold matters, and most GPs use the wrong one