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Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of kojic acid in F344 rats

362 In an experimental study in which osteoclast formation and bone resorption were induced in mice through lipopolysaccharide (LPS) administration, researchers discovered that simultaneous treatment with exendin-4 resulted in a significant decrease in the number of osteoclasts, the proportion of bone resorption pits, and the levels of the bone resorption marker CTX compared to injection with LPS alone

[DOI] [PMC free article] [PubMed] [Google Scholar] Vzina FA, Cantin AM

Stuhlmiller TJ, Miller SM, Zawistowski JS, Nakamura K, Beltran AS, Duncan JS, et al

Zeilstra, J

This results in decreasing the sympathetic nervous activity in the erectile tissue