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The goal is to maximize therapeutic benefitsimproved glycemic control and weight managementwhile minimizing side effects and supporting long-term adherence

Fat mass reduction The body composition substudy measured total fat mass changes using dual-energy X-ray absorptiometry, the gold standard for distinguishing fat from lean tissue

Price erosion and supply reliability Despite the promise of the pipeline, incumbent molecules injectable semaglutide and tirzepatide will likely continue to lead a much-expanded GLP-1 global market in 2035

Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

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However, the Administration left open the door to explore alternative pathways to coverage