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Gastroparesis remains one of the most treatment-resistant GI disorders precisely because existing drugs (metoclopramide, erythromycin, domperidone) only address downstream contractility without repairing the vagal signalling deficit

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Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Monitoring : Patients should have regular HbA1c monitoring (typically every 36 months) to assess treatment efficacy

The medications may also have direct effects on cancer cells and tumor growth, though this research is still developing