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Nrf2 activation mitigates this process by attenuating intracellular ROS accumulation, thereby indirectly suppressing inflammatory signals such as NF-B 43

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Preclinical studies using TLR9 antagonists or genetic deletion have shown attenuation of neuroinflammation and improved neuronal survival in models of CNS injury and disease [130]

Adequate dietary protein and progressive resistance training remain the most evidence-supported approaches to maintain muscle protein synthesis during weight loss

Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers