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What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide

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For many, this means dramatic weight loss often 1520% of body weight as well as improved blood sugar control

The incidence of the disease is approximately 1 in 100,000, and the mortality rate for infantile hypophosphatasia is as high as 50%