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Results Engineering of IgG1 for prolonged plasma half-life By scrutinizing a human FcRn:IgG1 Fc co-crystal structure 21 , we identified three Fc amino acid residues that were substituted with the rationale to improve pH-dependent receptor binding, namely Q311R, M428E and N434W (REW) (Fig

Research published in 2011 found that elderly subjects had markedly lower glutathione concentrations compared to younger adults, with 83% higher fractional synthesis rates in young people

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51 JandricI.VrcicH.Jandric BalenM.KolencD.BrcicL.RadicB.et al (2013)