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Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

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These effects include promoting neurotrophin synthesis, inhibiting neuronal death, and modulating inflammatory responses and antioxidant pathways

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Two columns in particular half-life and dosing convention carry a heavy caveat: the figures that circulate for both compounds are vendor and community conventions, not established human pharmacokinetics