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Interestingly, their analysis demonstrated that different GS-like enzymes accepted various alternate nucleophiles, including d-serine, non-natural amino acids, and alpha-amino alcohols, to yield a range of glutathione variants, but did not produce either serine- or glutamate-substituted analogs
BBB disruption in age and neurodegenerative disorders Disruption of the BBB coincides with healthy aging, but the characteristics of breakdown can become further exacerbated in neurodegenerative disorders (Table 1)
d , Sensitivity (area under the curve, AUC) of n = 760 cancer cell lines to GPX4 inhibitors RSL-3 and ML-210
Microglia seem to play an important and dynamic role in BBB integrity in response to different insults
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