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Amiodarone is a clinically approved antiarrhythmic agent, active by inhibiting Na + /K + -ATPase and multiple ions channels, including Ca 2+ channels (Zimetbaum, 2012

Clinical picture of arteriolosclerosis

Elevated HPHPA, a Clostridia metabolite measured on OAT, has been associated with altered dopamine-to-norepinephrine conversion and may be relevant in neurocognitive symptom presentations (Shaw, 2010)

Morant-Ferrando, B

A meta-analysis of randomized clinical trials has similarly highlighted significant effects on SBP, with mechanistic links to NO-mediated endothelial repair