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Study identifies gut-brain-immune network influencing effectiveness of GLP-1 agonists owenhaskins Dec 19, 2023 3 min read Researchers at the Lunenfeld-Tanenbaum Research Institute, part of Sinai Health, have discovered a gut-brain-immune network and posit a new gut-brain glucagon-like peptide 1 (GLP-1R) that controls inflammation across the body, a discovery which holds promise for understanding and treating metabolic diseases

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Am J Physiol Regul Integr Comp Physiol 2012;302:R751-R767

After 35, GLP-1 levels decline and for women, perimenopause accelerates this