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Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

doi: 10.1124/pr.117.014092 55

A comprehensive review study

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Both are driven by TNF-alpha, IL-17, and IL-23 overproduction

A February 2026 investigation by Undark established that the overwhelming majority of BPC-157 studies on PubMed include either Sikiric or his colleague Sven Seiwerth as a main author