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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

As a result, based on the limited research to date and methodological limitations, further research is warranted

\Exercise Mimetic: Boosts MOTS-C post-exercise to improve metabolic adaptations (Nature Communications, 2021)

Clinical use should remain conservative and individualized

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