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Cellular GSSG accumulation is limited by the fact that cells employ multiple redundant reductive pathways to reduce cytosolic GSSG or to actively export GSSG to the extracellular environment, for example by MRP1 in mammalian cells or to alternative subcellular compartments, for example by Ycf1 in yeast [21, 59]

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Structureactivity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

Parra, L

For instance, once the concentration of hydrogen peroxide reaches levels of 10 M under stress, various enzymes participating in the C 3 cycle, like fructose-1,6-bisphosphatase, sedoheptulose-1,7-bisphosphatase, and phosphoribulokinase, show 50% reduction in their activity [49, 50]

Arosio, E., De Marchi, S., Zannoni, M., Prior, M., & Lechi, A