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In the course of the infection, pathogens need iron to sustain their survival

Proc Natl Acad Sci USA 104:1662116626 Han J, Cheng FC, Yang Z, Dryhurst G (1999) Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinsons disease

Strikingly, KL1 enhanced antibiotic-mediated killing of both pathogens in macrophages (Fig

We first established a therapy model of NAC in our animal model

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Kumagai, H., Yoshikawa, T., Zempo-Miyaki, A., Myoenzono, K., Tsujimoto, T., Tanaka, K., & Maeda, S