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doi: 10.1152/physrev.1983.63.4.1420 17

These powerful reagents are used

Gastrointestinal side effects and injection site reactions are among the adverse effects reported in clinical trials, and these can influence daily functioning depending on when they occur

And the benefits might be partly result from decrease in lectin-like oxidized receptor1 (LOX-1) followed by significant declines in cellular ROS and NF-B signaling pathways

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Mean difference in pain reduction as measured on a 10-cm VAS, and 95% CIs were used for pooling continuous data from each trial