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2023 titled Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol, improvements in cognition and thiamine blood levels have been observed over about 14 days of supplementation

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Should I reconstitute the whole 100mg at once

PMID 1579111

Once it does its job, it becomes oxidized and "inactive." To stay effective, the body must constantly "recycle" it back into its active state

As well, the risk of bias was almost high in the included studies that might affect the quality of evidence