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lifetime decreased medical expense $62K JAMA Health Forum (2025): Showed that the cost per quality adjusted life year (QALY) for tirzepatide (Zepbound) was $197K and the cost per QALY for semaglutide (Wegovy) was $468K

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Quick Answer: GLP-1 injections begin suppressing appetite within one to two weeks, with measurable weight loss starting by week four and hemoglobin A1c reductions evident after 12 to 16 weeks

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Some patients find that lower doses (e.g., 1.7 mg) work well for sustaining results with fewer side effects