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Glucagon promotes hepatic fatty acid oxidation (fat burning in the liver) and reduces intrahepatic lipid accumulation, which is particularly beneficial for MASH/NAFLD

(2024, September) Retatrutide is a novel triple-agonist targeting GLP-1, GIP, and glucagon receptors, showing in phase 2 trials that it can deliver remarkably large weight losses (up to ~24% over 48 weeks in people with obesity) along with strong improvements in HbA1c, lipid profiles, liver fat (in NAFLD), insulin sensitivity, and other cardiometabolic markers

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30 in JAMA Ophthalmology

Eli Lilly is expected to present this data to the U.S

By utilizing this methodology, researchers have revealed that GLP-1RAs can exhibit affect the axon terminals of sensory neurons