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Using NanoBiT complementation, we found subtle differences in GLP-1R coupling to both G s and -arrestin-2 between exendin-4 and lixisenatide, although it is not clear whether this is sufficient to explain the significant differences in potency for cAMP signalling

Semaglutide injections, such as Ozempic and Wegovy, are designed for long-term weight management rather than rapid or short-term fixes

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NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons

Liraglutide is a daily injectable medication used for long-term weight management

Lu H, Zhang H, Jiang Y