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Natural: Synthetic cyanocobalamin requires conversion in the liver to become active, which means some people may not absorb it efficiently

For example, 3-HK scavenges NO [164], limiting lipid and protein oxidation, as observed in supernatants from rat cerebral cortex [163], and short-term exposure (100 M, 1 h) markedly enhances antioxidant capacity in C6 glioma cells by up to 400% [163]

A report from the European Hyperoxaluria Consortium (OxalEurope) Registry on a large cohort of patients with primary hyperoxaluria type 3

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