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The commenter also stated that this would cause an increase in employee time for coordinating data capture and ensuring quality data and that the cost would continue to increase as well because of the complexity of the requirements and the resources to create the data

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131 Nevertheless, most of the evidence gathered to date was derived from smaller mechanistic studies, and the few large randomized controlled trials have not shown a significant mortality benefit of using these agents

New patches appearing days after the original rash are a normal part of the same immune response, not evidence that the rash is actively contagious or spreading

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