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doi: 10.3389/fcimb.2024.1426340 Received 01 May 2024 Accepted 29 May 2024 Published 13 August 2024 Volume 14 - 2024 Edited by Rongrong Ma, Ningbo University, China Reviewed by Jianfei Lu, Ningbo University, China Yongxiang Yu, Chinese Academy of Fishery Sciences (CAFS), China Hui Xue, Freshwater Fisheries Research Institute of Jiangsu Province, China Updates Copyright 2024 Su, Gao, Shu, Cai, Fang, Lei, Li and Hu

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The esophageal, gastric, colorectal, and pancreatic cancers, in addition to HCC, are reviewed, and the role of melatonin in the regulation of specific pathways in each of the mentioned cancers, including Wnt/-catenin, PI3K/Akt/mTOR, MAPK/ERK, Hippo/YAP, NF- , IL-6 signaling, oxidative stress, apoptosis, and autophagy are discussed

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