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Role of electrostatic interactions in the reaction of NADPH-cytochrome P-450 reductase with cytochromes P-450 Arch Biochem Biophys 1988

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It was developed in the early 1990s by the Danish pharmaceutical company Novo Nordisk, who were looking for a long-acting yet therapeutically effective treatment of type 2 diabetes [1]

Medications like semaglutide and tirzepatide mimic this natural hormone but in a much more powerful and long-lasting way