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Additional information Peer review information Primary Handling Editor: Christoph Schmitt

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522 While hepatocyte- or intestine-specific deletion of FXR delays liver regeneration without causing mortality, global FXR KO mice exhibit severely impaired regeneration and high mortality rates

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As a regulatory recognised and validated in vitro model for the evaluation of carcinogenic potential, the Bhas 42 Cell Transformation Assay is widely used