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Testicular defense systems: immune privilege and innate immunity

Given the fact that SGLT2i and GLP1RA safely reduce HbA1c without increased risk of hypoglycemia or weight gain and have beneficial cardiorenal effects across a broad range of subjects with T2DM, we believe these agents should be considered regardless of the presence of CVD

After 52 weeks of treatment, saxagliptin and glipizide resulted in similar mean reductions from baseline in A1C when added to metformin HCl therapy (Table 9)