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31-33 Prevention of Retinopathy: One of the least-studied potential benefits of DPP-4 inhibitors is the ability to decrease blood flow and increase vasodilation, thereby preventing retinopathy in diabetic patients

This could be associated with the damage to cell component, basement membrane and epithelia by lipid peroxidation, protein denaturation and enzyme inactivation in vascular endothelial cells

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In healthy individuals, the incretin effect stimulates insulin secretion, accounting for about 70% of total insulin secretion, with GIP contributing two-thirds of this effect, which is higher than that of GLP-1