Gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 people): Often most pronounced during dose escalation, typically improving over time Diarrhoea (very common): Can range from mild to severe and may be difficult to distinguish from a Crohn's flare Vomiting (common, affecting up to 1 in 10 people): May contribute to dehydration and electrolyte imbalance Constipation (common): Paradoxically, some patients experience reduced bowel frequency Abdominal pain (common): Can mimic or exacerbate Crohn's-related pain These effects result primarily from delayed gastric emptying and altered gastrointestinal motility
Wood GC, Underwood EL, Croce MA, Swanson JM, Fabian TC
"I don't see this as something that clinicians are going to use to inform their practice," Andrea Ganna, a health data scientist at the University of Helsinki, told Nature in an article accompanying the research
metabolic drugs, CGMs, biosimilars), this mediator layer can accelerate adoption outside metros, drive education, fulfillment, adherence tracking all in one flow
Selenium is incorporated into glutathione peroxidase (GPx) - the selenoprotein enzyme that uses glutathione as its substrate to neutralize HO in thyroid cells
More than 300 organizations are participating as GUIDE Model sites across the U.S