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Key takeaway: No FDA-approved weight loss medication has produced greater weight loss than tirzepatide in controlled clinical settings

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Pierard-Franchimont C, Lesuisse M, Humbert P, Delvenne P, Pierard GE (2012) Toxic epidermal necrolysis and antifolate drugs in cancer chemotherapy

The mean reduction in body weight at 48 weeks was 24.2% in the 12-mg group the largest reduction observed to date in a Phase 2 trial of an anti-obesity medication. Jastreboff et al., New England Journal of Medicine, 2023 The Liver-Fat Result Beyond weight loss, retatrutide produced a result that surprised researchers: dramatic reductions in liver fat