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At each, binding produces Gs coupling, adenylyl-cyclase activation, cAMP elevation, and downstream signalling with tissue-specific outputs enhanced insulin secretion in -cells, appetite and energy-expenditure signalling in the CNS, lipid effects in adipose tissue, and fat-metabolism effects in the liver

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El manejo de la obesidad y de la diabetes tipo 2 suele incluir alimentacin, actividad fsica, seguimiento clnico y atencin de factores como la presin arterial, el colesterol, el sueo y la salud emocional

However, severe dizziness, fainting, or chest pain require immediate medical attention

Revising paragraphs (a)(5), (b)(5) and (6)

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