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Significant degradation has likely occurred over 8 to 12 hours at room temperature

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

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The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway