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While we believe that this is the first study to observe this relationship in PTSD, MPO has been positively correlated with duration of bipolar disorder (71), and higher MMP-9 has been reported in younger youth diagnosed with bipolar disorder compared to older adults (72)

Methods Animal experiment Male SHR and WKY rats, aged 2, 3, 4, 6, 8, 10, 12 and 16 weeks, were obtained from the Laboratory Animals Research Unit of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia and housed at room temperature with a 1212 h lightdark cycle (06001800 hours), and with access ad libitum to food and water throughout the experimental period