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Semaglutide Weight Loss Results by Timeline: What Clinical Trials Show Clinical trial data from the STEP program provides the clearest picture of what to expect from semaglutide at a 2.4 mg weekly dose

Some treat it as temporary (6 to 12 months) to reach a target weight, while others use it long-term or indefinitely for sustained weight management and metabolic health

By week 20, many patients achieve 15% to 22% weight reduction, with continued gradual loss possible over months of sustained treatment