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At a 10-unit dose delivering 1.0 mg or less, weight loss is unlikely to be rapid enough to trigger this effect

The qualifications include being an adult with a body mass index (BMI) of at least 30 mg/kg or higher, or a BMI of 27 mg/kg or higher, along with a minimum of one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol

Metabolism and Weight Management: As mentioned above, vitamin B12 helps break down fats, proteins, and carbohydrates, improving metabolism and supporting weight management

Hershman of Columbia University in New York, so this is not like a lot of studies where you find a statistically significant difference thats not clinically meaningful. In addition, the incidence of grade 3/4 neurotoxicity was 3.8% with ALC, much higher than the 0.5% seen with placebo

10.1038/s41746-022-00713-7 95 YamazakiT.MimuraI.TanakaT.NangakuM